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Before using or dispensing any product, read and carefully observe the label directions. The effectiveness of this product when used before bathing has not been evaluated. Reproduction in whole or in part without permission is prohibited. Avoid contact with the application area while it is wet and wash hands thoroughly with soap and warm water after handling. Cats ranged in age between 2 months and 17 years and weighed between 0.8 lbs (0.36 kg) and 21 lbs (9.62 kg). PROFENDER Topical Solution may be irritating to skin and eyes. A single treatment is effective and a second treatment should not be necessary. Reinfections are usually rare, but if it occurs, the dewormer may be reapplied after consulting a vet [3]. To ensure the entire contents of the tube are administered, place the tip of the tube on the skin and squeeze the entire contents directly onto the skin. Praziquantel is an isoquinoline cestocide. Topical Solution for the treatment and control of hookworm, roundworm and tapeworm infections in cats and kittens that are at least 8 weeks of age and weigh at least 2.2 lbs (1 kg). Studies performed in rats and rabbits suggest that emodepside may interfere with fetal development in those species. Anyone who has ever tried to give a recalcitrant cat a pill for any reason has wished for an alternative to the physical risks of shoving a worm pill down the throat of an animated, armed and annoyed cat. At the study conclusion, the 1X and 5X cats had fewer live heartworms recovered than the 0X group. Post-Approval Experience: The following adverse events are based-on post-approval adverse drug experience reporting. Profender (emodepside/praziquantel) Topical Solution. Treatment at the base of the head will minimize the opportunity for ingestion while grooming. Another cat exhibited tremors and lethargy. In yet other cases, you may see a cat with shaking and tremors because of this drug. The listing includes Adverse Events reported to CVM for products, such as Profender, that contain the combined active ingredients emodepside and praziquantel. 1. One cat treated with a vehicle placebo (formulation minus the active ingredients) showed salivation, gagging, lethargy and a swollen tongue. Use with caution in sick or debilitated cats. Your email address will not be published. However, in some cases, a cat who licks the application site may suffer more severe side effects than a cat who does not. This would most likely occur in cases where a pet owner either was not told that the drug is a topical drug or in cases of a pet owner failing to read the application instructions. Information contained on this site pertains only to the United States of America, and is not intended to provide adequate information for product use. PROFENDER Topical Solution is indicated for the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults) in cats. 20 - 0.35 mL tubes (5 blisters of 4 tubes), 40 - 0.35 mL tubes (10 blisters of 4 tubes), 20 - 0.7 mL tubes (5 blisters of 4 tubes), 40 - 0.7 mL tubes (10 blisters of 4 tubes), 20 - 1.12 mL tubes (5 blisters of 4 tubes), 40 - 1.12 mL tubes (10 blisters of 4 tubes), 8 - 0.35 mL tubes (2 blisters of 4 tubes), 8 - 1.12 mL tubes (2 blisters of 4 tubes). Of those, 606 received a single treatment with PROFENDER Topical Solution. Laboratory effectiveness studies: One cat died 10 days after receiving PROFENDER Topical Solution. Listings by active ingredient may represent more than one brand name. Lift tube away from the skin before releasing pressure on the tube. However, the licking and grooming can cause a cat to ingest the drug to the point that it may experience physical side effects. In the field study conducted at 13 veterinary clinics/hospitals, 837 purebred or crossbred cats from single and multi-cat households were enrolled to evaluate safety and effectiveness under field conditions of use. General Safety Study in Kittens: PROFENDER Topical Solution was topically applied at 0X (vehicle control), 1X, 3X and 5X the maximum dose to 48 healthy 8-week-old kittens every two weeks for six doses. The necropsy showed chronic active cholangiohepatitis. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. To report suspected adverse events and/or to obtain a copy of the MSDS or for technical assistance, call Bayer Animal Health at 1-800-633-3796. A few cats become agitated and nervous after the application of this drug. The most serious side effects occur if Profender is given orally instead of topically. Tell your vet about any health issues your cat may be having, and medications you are giving, especially if it is affected by adult heartworms because a study has indicated that the efficacy of the medication is likely to be less in such cases [3]. Adverse reactions reported by the cat owners included licking/excessive grooming in 18 cats (3.0%), scratching treatment site in 15 cats (2.5%), salivation in 10 cats (1.7%), lethargy in 10 cats (1.7%), alopecia in 8 cats (1.3%), agitation/nervousness in 7 cats (1.2%), vomiting in 6 cats (1.0%), diarrhea in 3 cats (0.5%), eye irritation in 3 cats (0.5%), respiratory irritation in 1 cat (0.2%) and shaking/tremors in 1 cat (0.2%). The physical side effects of Profender include hair loss and excessive salivation. However, with any medication, Profender has the potential for side effects, especially when given incorrectly. Box 390, Shawnee Mission, Kansas 66201 U.S.A. Profender provides treatment and control of common parasitic cat worms. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. A third 5X kitten experienced tremors the day after dosing. While holding the tube in an upright position, remove the cap from the tube. 2. In rare cases, the drug can trigger vomiting and diarrhoea. Keep out of reach of children. In some cases, death has been reported as an outcome of the adverse events listed. The Material Safety Data Sheet (MSDS) provides additional occupational safety information. Field study: In a controlled, double-masked field safety study, owners administered PROFENDER Topical Solution to 606 cats. 82482521/03615026/82482572/03615034/82482580/82482602, R.2. Remove one unit dose tube from the package. * Cats over 17.6 lbs should be treated with the appropriate combination of tubes. In some cases, you may notice eye and respiratory irritation. Other cats may scratch at the site where the drug was applied. Some cats will lick or groom excessively. Data from these studies demonstrated PROFENDER Topical Solution is safe and effective for the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults). These signs were self-limiting. In rare cases, the drug can trigger vomiting and diarrhoea. These signs were self-limiting. Bayer HealthCare LLC, Animal Health Division, P.O. As with other products of this type, Profender should be used on sick or ill cats or dogs only after a risk-benefit assessment by the vet. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth. Do not apply to broken skin or if hair coat is wet. Emodepside, a semi-synthetic molecule, is a cyclic depsipeptide. One 5X kitten experienced salivation and tremors and another 5X kitten experienced salivation on the day of dosing. He has been writing since 1987 and has written for NPR, AP, Boeing, Ford New Holland, Microsoft, RAHCO International, Umax Data Systems and other manufacturers in Taiwan. Profender is protected by the following U.S. In rare cases, the drug can trigger vomiting and diarrhea. The normally prescribed minimum dosage is 0.063 ml/lb (0.14 ml/kg) of Profender, equivalent to a combination of 5.45 mg/lb praziquantel and 1.36 mg/lb emodepside, applied topically [3, 10]. In other cases, Profender can cause a cat to become lethargic. In other cases, Profender can cause a cat to become lethargic. While the use of the drug did not appear to be the direct cause of death, treatment with the drug cannot be ruled out as a contributing factor (See PRECAUTIONS). In most cases, a single dose may effectively control the infection [3]. The physical side effects of Profender include hair loss and excessive salivation. Flattie V (AKA my flat self, AKA my visual foam standin) got to chat with two Bayer representatives at the May 2017 BlogPaws Conference about Profender for cats, a topical dewormer.Mom has used this treatment on me on more than one occasion to rid me of tapeworms. 5. All rights reserved. Not all adverse events are reported to FDA CVM. The recommended minimum dose is 1.36 mg/lb (3 mg/kg) emodepside + 5.45 mg/lb (12 mg/kg) praziquantel as a single topical dose. He studied creative writing at Mankato State University in Minnesota. Why is my cat drooling after I put flea medication on her?→. All adverse reactions were self-limiting. Profender is a broad-spectrum deworming medication used for controlling and treating parasitic infections [1, 2]. Oral Safety Studies in Cats: PROFENDER Topical Solution was administered orally at the recommended topical dose to young adult cats. The chemical name is Cyclo [D - 2 - hydroxypropanoyl - N - methyl - L - leucyl - 3 - [4 - (4 - morpholinyl)phenyl] - D - 2 - hydroxypropanoyl - N - methyl - L - leucyl - D - 2 - hydroxypropanoyl - N - methyl - L - leucyl - 3 - [4 - (4 - morpholinyl)phenyl] - D - 2 - hydroxypropanoyl - N - methyl - L - leucyl]. In some cases, you may notice eye and respiratory irritation. The chemical name is 2-Cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazine-2,1-a-isoquinoline-4-one. Required fields are marked *. Part the hair on the back of the cat’s neck at the base of the head, until the skin is visible. Select one or more newsletters to continue. cats image by Zbigniew Nowak from Fotolia.com.

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